Irvine, CA, December 15, 2023 – An oral and poster abstract, “Promising Safety and Anti-Lymphoma Efficacy of Autologous Pmb-CT01 (BAFFRCAR T Cell) Therapy in a First-in-Human Phase 1 Study”, has been published at American Society of Hematology Meeting 2023.
To find the article on the web: Paper: Promising Safety and Anti-Lymphoma Efficacy of Autologous Pmb-CT01 (BAFFRCAR T Cell) Therapy in a First-in-Human Phase 1 Study (confex.com)
About PMB-CT01
PMB-CT01 is a first-in-class BAFFR-targeted, autologous CAR T cell therapy. BAFF-R (B Cell Activating Factor Receptor), a tumor necrosis factor (TNF) receptor superfamily member, is the main receptor for BAFF expressing almost exclusively on B cells. Since BAFF-R signaling promotes normal B-cell proliferation and appears to be required for B-cell survival, it is unlikely tumor cells could escape immune responses via loss of BAFF-R antigen. This unique characteristic makes BAFF-R CAR T therapy a great potential treatment of B cell malignancies. BAFF-R CAR-T was constructed using the anti-BAFF-R scFv (single-chain fragment variable) antibodies with the 2nd generation signaling domains containing CD3ζ and 4-1BB. Our research has found that BAFFR-CAR T cells kill human lymphomas and leukemias in vitro as well as in animal models. PeproMene has licensed intellectual property relating to PMB-CT01, from City of Hope.
About PeproMene
PeproMene is a clinical-stage biotech company in Irvine, California developing novel therapies to treat cancers and immune disorders. PeproMene’s lead candidate, PMB-CT01 (BAFFR-CAR T Cells) is currently being investigated in phase 1 clinical trials to treat relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL; NCT04690595) and B-cell non-Hodgkin’s lymphoma (B-NHL; NCT05370430). PeproMene is also developing BAFFR Bispecific T Cell Engager and BAFFR-CAR NK cells.
For more information, contact Hazel Cheng, Ph.D. of PeproMene Bio Inc. at hazel.cheng@pepromenebio.com or visit www.pepromenebio.com.
